PF3D7_1253500

Genome location: Pf3D7_12_v3:2,183,464..2,184,168(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: MNFINFKIYIFFILFHTFILSNT

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1253500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.247 | MFS: -3.422 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4Q2

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215318

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 29

Non-coding: 5 | Synonymous: 8 | Nonsynonymous: 15 | Stop Codon: 1

Protein Information

Protein Length: 210 | Molecular Weight (kDa): 24.926

UniProt ID(s): Q8I4Q2

PDB ID(s): None

Isoelectric Point: 10.54

Protein Domain Annotations: