Genome location: Pf3D7_12_v3:2,196,157..2,197,122(+)
Genome classification: SubtelomericHypervariable
Product Description: Plasmodium exported protein (PHISTa), unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0043657 | host cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | not expressed | 0.00 | 1.00 |
| Schizont | possibly expressed | 0.00 | 1.00 |
| Gametocyte | not expressed | 0.00 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1253800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.349 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4P9
"Best" AlphaFill ligand hit: I3P (d-myo-inositol-1,4,5-triphosphate, Local RMSD=1.28) with 3V0H (Global RMSD=15.96)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 53
Non-coding: 6 | Synonymous: 14 | Nonsynonymous: 29 | Stop Codon: 4
Protein Length: 284 | Molecular Weight (kDa): 33.92
UniProt ID(s): Q8I4P9
PDB ID(s): None
Isoelectric Point: 5.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006526 | Exported protein, PHISTa/b/c, conserved domain, Plasmodium |
| InterPro | IPR019111 | Plasmodium RESA, N-terminal |
| PFam | PF09687 | Plasmodium RESA, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16507167 | Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. | Sargeant TJ, Marti M, ..., Cowman AF | 10.1186/gb-2006-7-2-r12 |