About Gene List

PF3D7_1254100

Genome location: Pf3D7_12_v3:2,204,724..2,205,714(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: stevor

SignalP Peptide: MNMYYLNMLLFTFLINTLVLP

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0033644 host cell membrane
Component GO:0005886 plasma membrane
Process GO:0020013 modulation by symbiont of host erythrocyte aggregation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.00 1.00
Trophozoite expressed 0.00 1.00
Schizont possibly expressed 0.00 1.00
Gametocyte possibly expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1254100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.996 | MFS: -1.922 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I4P6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 498

Non-coding: 53 | Synonymous: 124 | Nonsynonymous: 316 | Stop Codon: 5

Protein Information

Protein Length: 295 | Molecular Weight (kDa): 33.429

UniProt ID(s): Q8I4P6

PDB ID(s): None

Isoelectric Point: 8.52

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006374 Variant surface antigen Stevor
PFam PF17410 Variant surface antigen Stevor
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
25011110 STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediatesmerozoite invasion and rosetting. Niang M, Bei AK, ..., Preiser PR 10.1016/j.chom.2014.06.004
31363031 Dissecting the Gene Expression, Localization, Membrane Topology, and Function ofthe Plasmodium falciparum S TEVOR Protein Family Wichers JS, Scholz JAM, ..., Bachmann A 10.1128/mBio.01500-19