Genome location: Pf3D7_12_v3:2,228,632..2,229,740(-)
Genome classification: SubtelomericHypervariable
Product Description: rifin
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0020002 | host cell plasma membrane |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0046789 | host cell surface receptor binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0020033 | antigenic variation |
| Process | GO:0020035 | cytoadherence to microvasculature, mediated by symbiont protein |
| Process | GO:0042783 | evasion of host immune response |
| Process | GO:0020013 | modulation by symbiont of host erythrocyte aggregation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.00 | 1.00 |
| Trophozoite | expressed | 0.00 | 1.00 |
| Schizont | not expressed | 0.00 | 1.00 |
| Gametocyte | not expressed | nd | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1254800
Resistome Missense Mutations: P25L
Resistome Compounds with Missense Mutations: AN13762
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.505 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I4N9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 413
Non-coding: 25 | Synonymous: 112 | Nonsynonymous: 273 | Stop Codon: 3
Protein Length: 317 | Molecular Weight (kDa): 36.198
PDB ID(s): 6ZDX
Isoelectric Point: 9.62
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006373 | Variant surface antigen Rifin |
| PFam | PF02009 | Variant surface antigen Rifin |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10430943 | Rifins: a second family of clonally variant proteins expressed on the surface ofred cells infected with Plasmodium falciparum. | Kyes SA, Rowe JA, Kriek N, Newbold CI | 10.1073/pnas.96.16.9333 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25751816 | RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. | Goel S, Palmkvist M, ..., Wahlgren M | 10.1038/nm.3812 |
| 29187532 | Characterization of SPP inhibitors suppressing propagation of HCV and protozoa. | Hirano J, Okamoto T, ..., Matsuura Y | 10.1073/pnas.1712484114 |
| 32650338 | Structural basis for RIFIN-mediated activation of LILRB1 in malaria. | Harrison TE, Morch AM, ..., Higgins MK | 10.1038/s41586-020-2530-3 |
| 33647792 | Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptorLILRB2. | Sakoguchi A, Saito F, ..., Arase H | 10.1016/j.bbrc.2021.02.033 |
| 36918126 | Genetic diversity and natural selection of rif gene (PF3D7_1254800) in thePlasmodium falciparum global populations. | Xu SJ, Shen HM, ..., Chen JH | 10.1016/j.molbiopara.2023.111558 |