PF3D7_1300100 (VAR)

Genome location: Pf3D7_13_v3:21,364..28,787(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: erythrocyte membrane protein 1, PfEMP1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.02	0.99
Schizont	expressed	0.06	0.96
Gametocyte	expressed	0.04	0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1300100

Resistome Missense Mutations: D1072E, K1075E, S1921N, T2004K, E2033K

Resistome Compounds with Missense Mutations: AN13762, MMV011895

Resistome # Samples with Disruptive Mutations: 5 (4 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.096 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEV1

"Best" AlphaFill ligand hit: APC (alpha,beta-methyleneadenosine-5'-triphosphate, Local RMSD=0.68) with 5XOG (Global RMSD=27.71)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 2633

Non-coding: 419 | Synonymous: 593 | Nonsynonymous: 1612 | Stop Codon: 9

Protein Information

Protein Length: 2162 | Molecular Weight (kDa): 247.401

UniProt ID(s): A0A5P1A0K8, A0A5P1A0V4, A0A5P1A0X4, A0A5P1A105, A0A5P1A1B0, A0A5P1A1J1, A0A5P1A1R9, A0A5P1A1U1, A0A5P1A203, A0A5P1A2X1, Q25733, Q25734, Q8IEV1

PDB ID(s): None

Isoelectric Point: 4.96

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004258	Duffy-binding-like domain
InterPro	IPR008602	Duffy-antigen binding
InterPro	IPR029210	Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment
InterPro	IPR029211	Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment
InterPro	IPR041480	Cysteine-rich interdomain region 1 gamma
PFam	PF03011	Duffy-binding-like domain
PFam	PF05424	Duffy-antigen binding
PFam	PF15445	Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment
PFam	PF15447	Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment
PFam	PF18562	Cysteine-rich interdomain region 1 gamma
Superfamily	SSF140924	N/A