About Gene List

PF3D7_1301200 (GBPH2)

Genome location: Pf3D7_13_v3:72,267..74,990(-)

Genome classification: Core

Function and Localization

Product Description: GBPH2 protein

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.02 0.99
Trophozoite expressed 0.00 1.00
Schizont expressed 0.01 0.99
Gametocyte expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1301200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.169 | MFS: -2.687 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEU3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156154

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 300

Non-coding: 139 | Synonymous: 105 | Nonsynonymous: 55 | Stop Codon: 1

Protein Information

Protein Length: 377 | Molecular Weight (kDa): 42.597

UniProt ID(s): Q25859, Q8IEU3

PDB ID(s): None

Isoelectric Point: 4.61

Protein Domain Annotations:

Source Family ID Description
InterPro IPR003681 Glycophorin-binding protein
PFam PF02526 Glycophorin-binding protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12
17196675 Comparative transcriptomal analysis of isogenic Plasmodium falciparum clones ofdistinct antigenic and adhesive phenotypes Mok BW, Ribacke U, ..., Wahlgren M 10.1016/j.molbiopara.2006.11.006