About Gene List

PF3D7_1301400 (HYP12)

Genome location: Pf3D7_13_v3:82,128..84,689(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (hyp12), unknown function

SignalP Peptide: MFSSTTNIFFSLVFLVLLLLLSIKT

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0020020 food vacuole
Component GO:0030430 host cell cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.63 0.76
Trophozoite expressed 0.31 0.86
Schizont possibly expressed 0.07 0.96
Gametocyte not expressed 0.05 0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1301400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.232 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEJ2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215348

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 12 5 13
disruptive 15 56 22 47
missense 6 40 19 29

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 18 12 16
disruptive 37 95 40 83
missense 15 66 26 43

PlasmoDB Total SNPs: 111

Non-coding: 65 | Synonymous: 34 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 381 | Molecular Weight (kDa): 46.025

UniProt ID(s): Q8IEJ2

PDB ID(s): None

Isoelectric Point: 4.34

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
25956941 Trafficking of the signature protein of intra-erythrocytic Plasmodiumberghei-induced structures, IBIS1, to P. falciparum Maurer's clefts. Petersen W, Matuschewski K, Ingmundson A 10.1016/j.molbiopara.2015.04.005
27777305 Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates NovelLocalization Sequences That Target the Periphery of the Host Erythrocyte. Davies HM, Thalassinos K, Osborne AR 10.1074/jbc.M116.761213
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g