About Gene List

PF3D7_1301700 (CBP2)

Genome location: Pf3D7_13_v3:98,252..101,166(+)

Genome classification: Core

Function and Localization

Product Description: CX3CL1-binding protein 2

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0044228 host cell surface
Component GO:0005634 nucleus
Function GO:0005524 ATP binding
Function GO:0019956 chemokine binding
Function GO:0003676 nucleic acid binding
Function GO:0005515 protein binding
Process GO:0020035 cytoadherence to microvasculature, mediated by symbiont protein

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 1.68 0.40
Trophozoite expressed 0.36 0.84
Schizont expressed 0.19 0.90
Gametocyte not expressed 0.13 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1301700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.957 | MFS: -2.1 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEJ0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215313

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 6 3 8
disruptive 3 7 2 18
missense 3 7 2 16

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 9 8 15
disruptive 7 22 15 59
missense 5 15 11 43

PlasmoDB Total SNPs: 92

Non-coding: 83 | Synonymous: 8 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 245 | Molecular Weight (kDa): 28.255

UniProt ID(s): Q8IEJ0

PDB ID(s): None

Isoelectric Point: 10.53

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
20713134 Plasmodium falciparum Tudor Staphylococcal Nuclease interacting proteins suggestits role in nuclear as well as splicing processes. Hossain MJ, Korde R, ..., Malhotra P 10.1016/j.gene.2010.08.004
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
24983235 Inhibition of Plasmepsin V activity demonstrates its essential role in proteinexport, PfEMP1 display, and survival of malaria parasites. Sleebs BE, Lopaticki S, ..., Boddey JA 10.1371/journal.pbio.1001897
27653778 Plasmodium falciparum proteins involved in cytoadherence of infected erythrocytesto chemokine CX3CL1. Hermand P, Ciceron L, ..., Deterre P 10.1038/srep33786
31356937 CX3CL1 binding protein-2 (CBP2) of Plasmodium falciparum binds nucleic acids. Saxena R, Kaur J, ..., Mishra PC 10.1016/j.ijbiomac.2019.07.178
32184257 Role of Plasmodium falciparum Protein G EXP07 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum E MP1 Trafficking McHugh E, Carmo OMS, ..., Dixon MWA 10.1128/mBio.03320-19