About Gene List

PF3D7_1302000 (PTP6)

Genome location: Pf3D7_13_v3:112,224..115,251(-)

Genome classification: Core

Function and Localization

Product Description: EMP1-trafficking protein

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 2.06 0.25
Trophozoite expressed 0.75 0.62
Schizont expressed 0.29 0.84
Gametocyte not expressed 0.16 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1302000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -3.067 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEI6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532394

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 154

Non-coding: 95 | Synonymous: 49 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 312 | Molecular Weight (kDa): 36.532

UniProt ID(s): Q8IEI6, Q9NFG5

PDB ID(s): None

Isoelectric Point: 9.11

Protein Domain Annotations:

Source Family ID Description
InterPro IPR004855 Transcription factor IIA, alpha/beta subunit
PFam PF03153 Transcription factor IIA, alpha/beta subunit
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
32184257 Role of Plasmodium falciparum Protein G EXP07 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum E MP1 Trafficking McHugh E, Carmo OMS, ..., Dixon MWA 10.1128/mBio.03320-19
11955632 A potential membrane protein involved in pre-tRNA splicing of Schizosaccharomycespombe Kim M, Hwang K, Lim CJ, Kim D 10.1016/s0167-4781(01)00353-0