About Gene List

PF3D7_1302100 (G27/25)

Genome location: Pf3D7_13_v3:120,233..122,716(-)

Genome classification: Core

Function and Localization

Product Description: gamete antigen 27/25

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Function GO:0046983 protein dimerization activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.26 0.90
Trophozoite expressed 0.38 0.85
Schizont expressed 0.38 0.80
Gametocyte expressed 2.41 0.37

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1302100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.519 | MFS: -2.386 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEU2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533371

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 13 4 14
disruptive 4 6 1 14
missense 4 6 1 14

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 25 4 17
disruptive 4 10 11 34
missense 4 10 11 29

PlasmoDB Total SNPs: 121

Non-coding: 116 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 217 | Molecular Weight (kDa): 26.005

UniProt ID(s): Q27336, Q8IEU2, Q8MPL2

PDB ID(s): 1N81

Isoelectric Point: 6.84

Protein Domain Annotations:

Source Family ID Description
InterPro IPR015299 Gamete antigen, Plasmodium species
InterPro IPR036469 Gametocyte protein Pfg27 superfamily
PFam PF09216 Gamete antigen, Plasmodium species
Superfamily SSF89162 Gametocyte protein Pfg27 superfamily

Associated Publications

PMID Title Authors DOI/Link
19570101 The Plasmodium falciparum protein Pfg27 is dispensable for gametocyte and gameteproduction, but contributes to cell integrity during gametocytogenesis. Olivieri A, Camarda G, ..., Alano P 10.1111/j.1365-2958.2009.06762.x
19968995 Regulated oligomerisation and molecular interactions of the early gametocyteprotein Pfg27 in Plasmodium falciparum sexual differentiation. Camarda G, Bertuccini L, ..., Alano P 10.1016/j.ijpara.2009.11.006
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596