PF3D7_1302500

Genome location: Pf3D7_13_v3:131,261..141,355(-)

Genome classification: Core

Function and Localization

Product Description: AAA domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0003723	RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.46	0.78
Trophozoite	possibly expressed	0.75	0.60
Schizont	possibly expressed	0.32	0.81
Gametocyte	not expressed	1.05	0.48

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1302500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.829 | #Insertions: 11

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1401000)

Modification: Tagged | RMgm-4482

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
K9N7C7	Replicase polyprotein 1ab		OrthoMCL BLAST	med.21724, Compound 170SARS-CoV-2 3CLpro Inhibitors 2bSARS-CoV-2 3CLpro Inhibitors 3bSARS-CoV-2 3CLpro Inhibitors 2f...

Orthology Information

Ortholog Group (OrthoMCL): OG6_101455

Most Similar Human Ortholog: Not available

TM-align score: 0.00 | RMSD: 0.00

Seq Identity: 0.00 | Length: / 2743

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000107290	senataxin

Protein Information

Protein Length: 2743 | Molecular Weight (kDa): 325.172

UniProt ID(s): Q8IET9

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR041677	DNA2/NAM7 helicase, helicase domain
InterPro	IPR041679	DNA2/NAM7 helicase-like, C-terminal
PFam	PF13086	DNA2/NAM7 helicase, helicase domain
PFam	PF13087	DNA2/NAM7 helicase-like, C-terminal
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	47	176	83	160
disruptive	84	328	167	421
missense	61	293	151	366

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	74	281	120	166
disruptive	147	700	284	665
missense	103	568	226	455

PlasmoDB Total SNPs: 456

Non-coding: 237 | Synonymous: 138 | Nonsynonymous: 81 | Stop Codon: 0