PF3D7_1302900

Genome location: Pf3D7_13_v3:154,555..157,791(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.07	0.96
Trophozoite	expressed	0.20	0.88
Schizont	not expressed	0.02	0.99
Gametocyte	possibly expressed	0.19	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1302900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.05 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1401400)

Relative Growth Rate: 0.07 ± 0.04
Confidence: 8.03

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IET6

"Best" AlphaFill ligand hit: UPG (uridine-5'-diphosphate-glucose, Local RMSD=0.83) with 7UBY (Global RMSD=14.29)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156431

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	41	25	58
disruptive	23	99	59	142
missense	23	98	58	131

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	75	40	54
disruptive	38	229	101	222
missense	34	207	90	146

PlasmoDB Total SNPs: 174

Non-coding: 84 | Synonymous: 48 | Nonsynonymous: 40 | Stop Codon: 2

Protein Information

Protein Length: 800 | Molecular Weight (kDa): 95.611

UniProt ID(s): Q8IET6

PDB ID(s): None

Isoelectric Point: 9.86

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A