Genome location: Pf3D7_13_v3:158,048..158,778(+)
Genome classification: Core
Product Description: ATP synthase-associated protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.11 | 0.95 |
| Trophozoite | expressed | 0.67 | 0.62 |
| Schizont | expressed | 0.12 | 0.92 |
| Gametocyte | expressed | 0.46 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1303000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.677 | MFS: -2.209 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1401500)
Modification: Disrupted | RMgm-490
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IET5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 7 | 2 | 9 |
| disruptive | 1 | 7 | 3 | 19 |
| missense | 1 | 7 | 3 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 13 | 5 | 9 |
| disruptive | 2 | 21 | 16 | 26 |
| missense | 2 | 18 | 16 | 20 |
PlasmoDB Total SNPs: 35
Non-coding: 26 | Synonymous: 7 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 117 | Molecular Weight (kDa): 13.788
UniProt ID(s): Q8IET5
PDB ID(s): None
Isoelectric Point: 8.65
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |