PF3D7_1303200 (VAMP8)

Genome location: Pf3D7_13_v3:160,039..162,263(-)

Genome classification: Core

Function and Localization

Product Description: SNARE protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1303200.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.155 | MFS: -2.914 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1401700)

• Relative Growth Rate: 0.99 ± 0.08
• Confidence: 6.46

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1401700)

Modification: Disrupted | RMgm-3729

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IET3

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101193

Most Similar Human Ortholog: E5RH06

TM-align score: 0.73 | RMSD: 1.35

Seq Identity: 0.30 | Length: 50 / 208

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 118

Non-coding: 112 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 208 | Molecular Weight (kDa): 24.947

UniProt ID(s): Q0ZAF6, Q8IET3

PDB ID(s): None

Isoelectric Point: 6.12

Protein Domain Annotations: