PF3D7_1303300

Genome location: Pf3D7_13_v3:162,566..164,742(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.21	0.90
Trophozoite	no data	0.52	0.71
Schizont	no data	0.10	0.93
Gametocyte	no data	0.73	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1303300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.426 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IET2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104035

Most Similar Human Ortholog: X6REY2

TM-align score: 0.80 | RMSD: 2.05

Seq Identity: 0.19 | Length: 120 / 320

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000119328	actin binding transcription modulator

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	23	12	23
disruptive	9	62	21	61
missense	9	59	20	51

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	41	17	24
disruptive	21	127	44	116
missense	17	111	38	67

PlasmoDB Total SNPs: 88

Non-coding: 44 | Synonymous: 32 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 320 | Molecular Weight (kDa): 38.296

UniProt ID(s): Q8IET2

PDB ID(s): None

Isoelectric Point: 8.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011053	Single hybrid motif
InterPro	IPR039169	Protein Abitram
PFam	N/A	N/A
Superfamily	SSF51230	Single hybrid motif