PF3D7_1303700

Genome location: Pf3D7_13_v3:180,206..184,621(+)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	not expressed	0.35	0.80
Schizont	possibly expressed	0.71	0.62
Gametocyte	possibly expressed	0.92	0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1303700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: -3.15 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IES8

"Best" AlphaFill ligand hit: CP (phosphoric acid mono(formamide)ester, Local RMSD=0.19) with 4NF2 (Global RMSD=13.56)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532726

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	67	40	94
disruptive	36	160	101	248
missense	25	149	93	224

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	29	135	68	103
disruptive	70	379	197	338
missense	44	328	167	248

PlasmoDB Total SNPs: 273

Non-coding: 172 | Synonymous: 56 | Nonsynonymous: 45 | Stop Codon: 0

Protein Information

Protein Length: 1045 | Molecular Weight (kDa): 124.89

UniProt ID(s): Q8IES8

PDB ID(s): None

Isoelectric Point: 10.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
InterPro	IPR019734	Tetratricopeptide repeat
PFam	N/A	N/A
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily
Superfamily	SSF54534