PF3D7_1303800

Genome location: Pf3D7_13_v3:184,641..214,069(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1303800

Resistome Missense Mutations: K164M, N425K

Resistome Compounds with Missense Mutations: MMV009108, MMV665794

Resistome # Samples with Disruptive Mutations: 7 (6 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.354 | #Insertions: 11

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_153917

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 1278

Non-coding: 118 | Synonymous: 536 | Nonsynonymous: 624 | Stop Codon: 0

Protein Information

Protein Length: 9271 | Molecular Weight (kDa): 1111.791

UniProt ID(s): Q8IES7

PDB ID(s): None

Isoelectric Point: 9.34

Protein Domain Annotations: