PF3D7_1303900

Genome location: Pf3D7_13_v3:215,291..216,331(+)

Genome classification: Core

Function and Localization

Product Description: GINS complex subunit Psf3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.00	1.00
Trophozoite	expressed	0.01	0.99
Schizont	expressed	0.01	0.99
Gametocyte	expressed	0.22	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1303900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.146 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1402400)

Relative Growth Rate: 0.98 ± 0.12
Confidence: 5.68

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1402400)

Modification: Disrupted | RMgm-3732

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H597

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_136404

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	16	12	24
disruptive	1	11	4	17
missense	1	11	4	16

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	33	14	11
disruptive	2	34	15	40
missense	1	26	14	34

PlasmoDB Total SNPs: 70

Non-coding: 67 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 203 | Molecular Weight (kDa): 23.875

UniProt ID(s): C0H597

PDB ID(s): None

Isoelectric Point: 4.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010492	GINS complex, subunit Psf3
InterPro	IPR021151	GINS subunit, domain A
PFam	PF05916	GINS subunit, domain A
Superfamily	N/A	N/A