Product Description: condensin complex subunit 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000796 | condensin complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0044547 | DNA topoisomerase binding |
| Function | GO:0072587 | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity |
| Function | GO:0003682 | chromatin binding |
| Process | GO:0007076 | mitotic chromosome condensation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | possibly expressed | 0.40 | 0.76 |
| Schizont | expressed | 0.57 | 0.65 |
| Gametocyte | possibly expressed | 0.35 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1304000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.134 | MFS: -2.889 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1402500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H598
"Best" AlphaFill ligand hit: H7S ((3s)-3-(5-fluoro-1h-indol-3-yl)pyrrolidine-2,5-dione, Local RMSD=0.76) with 6PYY (Global RMSD=22.94)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103100
Most Similar Human Ortholog: C9JZP1
TM-align score: 0.29 | RMSD: 6.19
Seq Identity: 0.05 | Length: 112 / 1024
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000121152 | non-SMC condensin I complex subunit H |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 83 | 37 | 60 |
| disruptive | 20 | 101 | 70 | 156 |
| missense | 19 | 94 | 66 | 143 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 139 | 39 | 85 |
| disruptive | 40 | 240 | 137 | 225 |
| missense | 34 | 215 | 121 | 171 |
PlasmoDB Total SNPs: 266
Non-coding: 170 | Synonymous: 71 | Nonsynonymous: 25 | Stop Codon: 0
Protein Length: 1024 | Molecular Weight (kDa): 119.218
UniProt ID(s): C0H598
PDB ID(s): None
Isoelectric Point: 4.64
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR022816 | Condensin complex subunit 2/barren |
| PFam | PF05786 | Condensin complex subunit 2/barren |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 32049018 | Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and AreEssential for Parasite Proliferation and Transmission. | Pandey R, Abel S, ..., Tewari R | 10.1016/j.celrep.2020.01.033 |