PF3D7_1304200 (MIT2)

Genome location: Pf3D7_13_v3:226,669..229,688(-)

Genome classification: Core

Function and Localization

Product Description: CorA-like Mg2+ transporter protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0015095	magnesium ion transmembrane transporter activity
Process	GO:0015693	magnesium ion transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	nd	nd
Trophozoite	not expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	possibly expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1304200.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.243 | MFS: -3.37 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1402700)

Relative Growth Rate: 0.96 ± 0.10
Confidence: 5.94

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1402700)

Modification: Disrupted | RMgm-3735

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H599

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_132831

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	28	17	28
disruptive	4	13	9	28
missense	3	9	8	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	57	21	35
disruptive	8	36	26	75
missense	4	25	20	58

PlasmoDB Total SNPs: 189

Non-coding: 139 | Synonymous: 39 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 468 | Molecular Weight (kDa): 54.899

UniProt ID(s): A0A143ZWJ6

PDB ID(s): None

Isoelectric Point: 7.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002523	Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB
InterPro	IPR039204	Magnesium transporter MRS2-like
PFam	PF01544	Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB
Superfamily	SSF144083	N/A