Product Description: small heat shock protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0043621 | protein self-association |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0051259 | protein complex oligomerization |
| Process | GO:0006457 | protein folding |
| Process | GO:0009408 | response to heat |
| Process | GO:0042542 | response to hydrogen peroxide |
| Process | GO:0000302 | response to reactive oxygen species |
| Process | GO:0009651 | response to salt stress |
| Process | GO:0006986 | response to unfolded protein |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.84 | 0.55 |
| Schizont | expressed | 0.08 | 0.95 |
| Gametocyte | expressed | 0.88 | 0.54 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1304500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.102 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1403000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1403000)
Modification: Disrupted | RMgm-4291
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IES0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 17 | 3 | 19 |
| disruptive | 2 | 13 | 10 | 35 |
| missense | 2 | 13 | 10 | 30 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 27 | 8 | 20 |
| disruptive | 8 | 37 | 25 | 54 |
| missense | 4 | 33 | 20 | 45 |
PlasmoDB Total SNPs: 58
Non-coding: 48 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 211 | Molecular Weight (kDa): 25.195
UniProt ID(s): Q8IES0
PDB ID(s): None
Isoelectric Point: 6.36
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002068 | Alpha crystallin/Hsp20 domain |
| InterPro | IPR008978 | HSP20-like chaperone |
| InterPro | IPR031107 | Small heat shock protein HSP20 |
| PFam | PF00011 | Alpha crystallin/Hsp20 domain |
| Superfamily | SSF49764 | HSP20-like chaperone |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |