PF3D7_1304600

Genome location: Pf3D7_13_v3:236,907..241,351(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast
Component	GO:0005634	nucleus
Function	GO:0016279	protein-lysine N-methyltransferase activity
Process	GO:0018026	peptidyl-lysine monomethylation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.12	0.95
Trophozoite	expressed	0.77	0.59
Schizont	possibly expressed	0.07	0.96
Gametocyte	not expressed	0.69	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1304600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.086 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1403100)

Modification: Disrupted | RMgm-3736

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IER9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119633

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	62	48	100
disruptive	68	261	143	289
missense	40	218	114	246

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	157	65	103
disruptive	115	539	207	429
missense	67	432	154	268

PlasmoDB Total SNPs: 192

Non-coding: 28 | Synonymous: 84 | Nonsynonymous: 80 | Stop Codon: 0

Protein Information

Protein Length: 1290 | Molecular Weight (kDa): 155.219

UniProt ID(s): Q8IER9

PDB ID(s): None

Isoelectric Point: 8.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF82199	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895