Product Description: cyclin
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| Process | GO:0051726 | regulation of cell cycle |
| Process | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.04 | 0.97 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | not expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1304700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.125 | MFS: -3.251 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1403200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q76NM8
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=17.64) with 8D0Q (Global RMSD=20.26)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| O75909 | Cyclin-K | Homo sapiens | OrthoDB | US11390618, Example 1US10894788, Example 2US10894788, Example 3US11390618, Example 4... |
| O60563 | Cyclin-T1/Cyclin-dependent kinase 9 | Homo sapiens | OrthoDB | CDK Inhibitor, 14-Arylazo-3,5-diamino-1H-pyrazole 26b4-Arylazo-3,5-diamino-1H-pyrazole 30bCHEMBL1823556... |
Ortholog Group (OrthoMCL): OG6_102010
Most Similar Human Ortholog: J3QSH2
TM-align score: 0.91 | RMSD: 1.33
Seq Identity: 0.32 | Length: 85 / 274
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000163660 | cyclin L1 |
| ENSG00000221978 | cyclin L2 |
Protein Length: 274 | Molecular Weight (kDa): 32.614
PDB ID(s): None
Isoelectric Point: 8.95
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004367 | Cyclin, C-terminal domain |
| InterPro | IPR006671 | Cyclin, N-terminal |
| InterPro | IPR013763 | Cyclin-like |
| InterPro | IPR036915 | Cyclin-like superfamily |
| InterPro | IPR043198 | Cyclin/Cyclin-like subunit Ssn8 |
| PFam | PF00134 | Cyclin, N-terminal |
| PFam | PF02984 | Cyclin, C-terminal domain |
| Superfamily | SSF47954 | Cyclin-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 24 | 8 | 23 |
| disruptive | 7 | 36 | 18 | 50 |
| missense | 7 | 36 | 16 | 48 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 41 | 9 | 25 |
| disruptive | 13 | 76 | 37 | 68 |
| missense | 11 | 70 | 31 | 55 |
PlasmoDB Total SNPs: 131
Non-coding: 110 | Synonymous: 16 | Nonsynonymous: 5 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12869562 | Identification and initial characterization of three novel cyclin-relatedproteins of the human malaria parasite Plasmodium falciparum. | Merckx A, Le Roch K, ..., Doerig C | 10.1074/jbc.M301625200 |
| 23909752 | The cooperative roles of PHO80-like cyclins in regulating the G1/S transition andposterior cytoskeletal morphogenesis in Trypanosoma brucei | Liu Y, Hu H, Li Z | 10.1111/mmi.12352 |
| 28938001 | Cell cycle stage-specific transcriptional activation of cyclins mediated byHAT2-dependent H4K10 acetylation of promoters in Leishmania donovani | Chandra U, Yadav A, Kumar D, Saha S | 10.1371/journal.ppat.1006615 |