About Gene List

PF3D7_1305100 (AMR3)

Genome location: Pf3D7_13_v3:252,020..254,299(-)

Genome classification: Core

Function and Localization

Product Description: protein AMR3

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Process GO:0009657 plastid organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.98
Trophozoite expressed 0.53 0.69
Schizont expressed 0.47 0.73
Gametocyte expressed 0.52 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1305100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.191 | MFS: -3.184 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IER5

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.79) with 5BN3 (Global RMSD=27.20)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171414

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 19 12 30
disruptive 7 32 34 60
missense 7 30 32 54

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 38 18 40
disruptive 19 95 48 105
missense 14 80 44 79

PlasmoDB Total SNPs: 42

Non-coding: 23 | Synonymous: 13 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 420 | Molecular Weight (kDa): 50.564

UniProt ID(s): Q8IER5

PDB ID(s): None

Isoelectric Point: 10.27

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895
30726238 A mutagenesis screen for essential plastid biogenesis genes in human malariaparasites. Tang Y, Meister TR, ..., Yeh E 10.1371/journal.pbio.3000136