Product Description: translational activator GCN1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.01 | 0.56 |
| Trophozoite | expressed | 1.36 | 0.36 |
| Schizont | expressed | 0.30 | 0.83 |
| Gametocyte | expressed | 1.15 | 0.44 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1305300
Resistome Missense Mutations: L1774F
Resistome Compounds with Missense Mutations: Verapamil
Resistome # Samples with Disruptive Mutations: 5 (4 missense, 4 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.752 | #Insertions: 6
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102176
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 3525
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000089154 | GCN1 activator of EIF2AK4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 37 | 163 | 94 | 278 |
| disruptive | 101 | 437 | 275 | 673 |
| missense | 77 | 402 | 257 | 626 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 57 | 305 | 184 | 293 |
| disruptive | 166 | 898 | 472 | 809 |
| missense | 123 | 793 | 419 | 708 |
PlasmoDB Total SNPs: 382
Non-coding: 140 | Synonymous: 119 | Nonsynonymous: 123 | Stop Codon: 0
Protein Length: 3525 | Molecular Weight (kDa): 418.581
UniProt ID(s): C0H5A0
PDB ID(s): None
Isoelectric Point: 7.06
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR033173 | Translational activator Gcn1 |
| PFam | N/A | N/A |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 37043534 | Differential requirements for P stalk components in activating yeast proteinkinase Gcn2 by stalled ribosomes during stress | Gupta R, Hinnebusch AG | 10.1073/pnas.2300521120 |
| 34900236 | Ribo-Seq and RNA-Seq of TMA46 ( DFRP1) and GIR2 ( DFRP2) knockout yeast strains | Egorov AA, Makeeva DS, ..., Dmitriev SE | 10.12688/f1000research.74727.1 |