PF3D7_1305400

Genome location: Pf3D7_13_v3:268,764..270,974(-)

Genome classification: Core

Function and Localization

Product Description: AAR2 protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Process	GO:0000244	spliceosomal tri-snRNP complex assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.16	0.92
Trophozoite	possibly expressed	0.27	0.83
Schizont	possibly expressed	0.04	0.97
Gametocyte	not expressed	0.35	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1305400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.849 | MFS: -2.194 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1403900)

Relative Growth Rate: 0.04 ± 0.07
Confidence: 6.75

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IER1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103436

Most Similar Human Ortholog: Q9Y312

TM-align score: 0.75 | RMSD: 3.45

Seq Identity: 0.19 | Length: 333 / 609

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000131043	AAR2 splicing factor

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	41	12	38
disruptive	14	111	57	135
missense	13	109	56	125

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	69	22	46
disruptive	38	231	85	201
missense	31	209	73	145

PlasmoDB Total SNPs: 77

Non-coding: 34 | Synonymous: 19 | Nonsynonymous: 24 | Stop Codon: 0

Protein Information

Protein Length: 609 | Molecular Weight (kDa): 73.485

UniProt ID(s): Q8IER1

PDB ID(s): None

Isoelectric Point: 4.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007946	A1 cistron-splicing factor, AAR2
InterPro	IPR033648	AAR2, C-terminal
PFam	PF05282	A1 cistron-splicing factor, AAR2
Superfamily	N/A	N/A