PF3D7_1305600 (S2P)

Genome location: Pf3D7_13_v3:273,852..275,740(-)

Genome classification: Core

Function and Localization

Product Description: site-2 protease S2P, putative

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.05	0.96
Schizont	no data	0.03	0.98
Gametocyte	no data	0.04	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1305600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.243 | MFS: -2.554 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1404100)

Relative Growth Rate: 0.77 ± 0.08
Confidence: 6.34

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1404100)

Modification: Tagged | RMgm-4116

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEQ9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107106

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	23	9	21
disruptive	1	15	7	28
missense	1	15	7	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	34	18	28
disruptive	5	33	26	57
missense	4	30	24	44

PlasmoDB Total SNPs: 87

Non-coding: 66 | Synonymous: 16 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 330 | Molecular Weight (kDa): 38.979

UniProt ID(s): Q8IEQ9

PDB ID(s): None

Isoelectric Point: 8.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A