PF3D7_1305700

Genome location: Pf3D7_13_v3:277,139..277,729(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MPHHLTSFVAALTGSISS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.00	1.00
Trophozoite	expressed	0.01	1.00
Schizont	expressed	0.00	1.00
Gametocyte	expressed	0.01	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1305700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.136 | MFS: -2.717 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEQ8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533502

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	11	2	20
disruptive	4	21	12	40
missense	3	21	12	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	17	11	19
disruptive	8	47	17	53
missense	7	40	16	41

PlasmoDB Total SNPs: 9

Non-coding: 0 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 196 | Molecular Weight (kDa): 21.632

UniProt ID(s): Q8IEQ8

PDB ID(s): None

Isoelectric Point: 4.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A