PF3D7_1305800

Genome location: Pf3D7_13_v3:278,294..279,133(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	not expressed	0.25	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1305800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -2.754 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1404300)

Relative Growth Rate: 1.03 ± 0.15
Confidence: 5.23

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1404300)

Modification: Disrupted | RMgm-3745

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEQ7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532776

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	8	19
disruptive	5	38	24	49
missense	5	36	24	49

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	26	15	21
disruptive	13	77	40	77
missense	10	72	37	61

PlasmoDB Total SNPs: 17

Non-coding: 0 | Synonymous: 7 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 279 | Molecular Weight (kDa): 33.225

UniProt ID(s): Q8IEQ7

PDB ID(s): None

Isoelectric Point: 8.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A