PF3D7_1305900

Genome location: Pf3D7_13_v3:279,287..282,199(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	expressed	0.46	0.74
Schizont	not expressed	0.23	0.84
Gametocyte	possibly expressed	0.47	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1305900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.889 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1404400)

Relative Growth Rate: 1.05 ± 0.11
Confidence: 5.82

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1404400)

Modification: Disrupted | RMgm-3746

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEQ6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215367

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	21	12	40
disruptive	11	60	41	92
missense	11	58	39	84

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	52	24	44
disruptive	20	138	75	122
missense	17	125	64	96

PlasmoDB Total SNPs: 108

Non-coding: 84 | Synonymous: 9 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 475 | Molecular Weight (kDa): 57.924

UniProt ID(s): Q8IEQ6

PDB ID(s): None

Isoelectric Point: 9.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A