PF3D7_1306000

Genome location: Pf3D7_13_v3:283,370..287,947(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.29	0.85
Schizont	possibly expressed	0.95	0.53
Gametocyte	not expressed	0.22	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1306000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.89 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1404500)

Modification: Disrupted | RMgm-3747

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEQ5

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=4.06) with 6JWQ (Global RMSD=20.49)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533629

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	81	34	87
disruptive	51	262	135	318
missense	46	243	128	284

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	153	52	92
disruptive	114	516	187	384
missense	86	459	166	290

PlasmoDB Total SNPs: 167

Non-coding: 46 | Synonymous: 53 | Nonsynonymous: 67 | Stop Codon: 1

Protein Information

Protein Length: 1341 | Molecular Weight (kDa): 160.57

UniProt ID(s): Q8IEQ5

PDB ID(s): None

Isoelectric Point: 9.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A