PF3D7_1306100

Genome location: Pf3D7_13_v3:287,950..288,637(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	1.00
Trophozoite	no data	0.10	0.93
Schizont	no data	0.02	0.98
Gametocyte	no data	0.12	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1306100

Resistome Missense Mutations: N117H

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.12 | MFS: -2.824 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1404600)

Relative Growth Rate: 0.07 ± 0.08
Confidence: 6.53

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5A1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532568

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	6	5	8
disruptive	7	17	12	20
missense	7	17	12	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	11	7	8
disruptive	10	45	16	30
missense	9	37	9	20

PlasmoDB Total SNPs: 20

Non-coding: 6 | Synonymous: 10 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 132 | Molecular Weight (kDa): 15.875

UniProt ID(s): C0H5A1

PDB ID(s): None

Isoelectric Point: 10.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A