PF3D7_1306200

Genome location: Pf3D7_13_v3:288,740..291,710(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MKLSLVIFCIVIIFFKENIS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	expressed	0.36	0.77
Schizont	expressed	0.14	0.90
Gametocyte	expressed	0.12	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1306200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.148 | MFS: -3.248 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1404700)

Relative Growth Rate: 0.17 ± 0.11
Confidence: 5.75

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEQ3

"Best" AlphaFill ligand hit: TBR (dodecabromohexatantalum, Local RMSD=0.09) with 2BVL (Global RMSD=14.57)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146118

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	26	11	25
disruptive	10	40	26	73
missense	10	40	26	66

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	42	21	48
disruptive	16	108	50	102
missense	14	94	38	78

PlasmoDB Total SNPs: 112

Non-coding: 82 | Synonymous: 19 | Nonsynonymous: 10 | Stop Codon: 1

Protein Information

Protein Length: 478 | Molecular Weight (kDa): 56.811

UniProt ID(s): Q8IEQ3

PDB ID(s): None

Isoelectric Point: 9.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	N/A	N/A
Superfamily	SSF53474	Alpha/Beta hydrolase fold