PF3D7_1306500

Genome location: Pf3D7_13_v3:299,720..314,523(+)

Genome classification: Core

Function and Localization

Product Description: MORN repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 10

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	not expressed	0.24	0.88
Schizont	not expressed	0.18	0.90
Gametocyte	not expressed	1.85	0.28

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1306500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.051 | #Insertions: 13

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1405000)

Relative Growth Rate: 1.00 ± 0.13
Confidence: 5.45

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1405000)

Modification: Disrupted | RMgm-3752

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533684

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	31	230	144	327
disruptive	114	636	366	845
missense	99	610	356	773

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	72	459	220	377
disruptive	250	1405	617	1149
missense	186	1233	535	884

PlasmoDB Total SNPs: 428

Non-coding: 100 | Synonymous: 177 | Nonsynonymous: 151 | Stop Codon: 0

Protein Information

Protein Length: 4313 | Molecular Weight (kDa): 520.222

UniProt ID(s): C0H5A3

PDB ID(s): None

Isoelectric Point: 9.46

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003409	MORN motif
PFam	N/A	N/A
Superfamily	SSF82185	N/A