PF3D7_1306700

Genome location: Pf3D7_13_v3:318,031..320,148(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.01	0.99
Trophozoite	expressed	0.10	0.93
Schizont	possibly expressed	0.02	0.99
Gametocyte	not expressed	0.10	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1306700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.5 | MFS: -2.241 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1405200)

Relative Growth Rate: 1.05 ± 0.14
Confidence: 5.30

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1405200)

Modification: Disrupted | RMgm-3754

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEP8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532953

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	24	10	34
disruptive	10	59	34	87
missense	10	57	34	73

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	50	21	32
disruptive	20	138	58	132
missense	17	125	50	86

PlasmoDB Total SNPs: 92

Non-coding: 64 | Synonymous: 10 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 359 | Molecular Weight (kDa): 42.67

UniProt ID(s): Q8IEP8

PDB ID(s): None

Isoelectric Point: 5.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A