PF3D7_1306800

Genome location: Pf3D7_13_v3:320,722..322,613(-)

Genome classification: Core

Function and Localization

Product Description: RED-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.31	0.84
Trophozoite	no data	0.39	0.76
Schizont	no data	0.38	0.76
Gametocyte	no data	0.35	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1306800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -0.471 | #Insertions: 2

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1405300)

Relative Growth Rate: 0.07 ± 0.14
Confidence: 5.29

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEP7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104385

Most Similar Human Ortholog: D6RAH1

TM-align score: 0.38 | RMSD: 2.71

Seq Identity: 0.03 | Length: 36 / 400

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000113141	IK cytokine

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	16	15	30
disruptive	6	59	27	54
missense	6	58	25	51

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	42	19	32
disruptive	22	112	48	103
missense	14	104	42	77

PlasmoDB Total SNPs: 51

Non-coding: 24 | Synonymous: 13 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 400 | Molecular Weight (kDa): 47.757

UniProt ID(s): Q8IEP7

PDB ID(s): None

Isoelectric Point: 9.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012916	RED-like, N-terminal
InterPro	IPR039896	Protein Red-like
PFam	PF07808	RED-like, N-terminal
Superfamily	N/A	N/A