Product Description: U1 small nuclear ribonucleoprotein A, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005685 | U1 snRNP |
| Component | GO:0005634 | nucleus |
| Component | GO:0005681 | spliceosomal complex |
| Function | GO:0030619 | U1 snRNA binding |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.31 | 0.84 |
| Trophozoite | expressed | 0.31 | 0.80 |
| Schizont | expressed | 0.12 | 0.92 |
| Gametocyte | expressed | 0.35 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1306900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.192 | MFS: -2.789 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1405400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H5A4
"Best" AlphaFill ligand hit: 15P (peg 1500, Local RMSD=0.09) with 6F4J (Global RMSD=3.52)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100753
Most Similar Human Ortholog: M0R0G9
TM-align score: 0.92 | RMSD: 1.63
Seq Identity: 0.39 | Length: 87 / 449
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000077312 | small nuclear ribonucleoprotein polypeptide A |
| ENSG00000125870 | small nuclear ribonucleoprotein polypeptide B2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 20 | 10 | 33 |
| disruptive | 11 | 44 | 33 | 70 |
| missense | 10 | 43 | 31 | 62 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 49 | 22 | 34 |
| disruptive | 17 | 107 | 63 | 124 |
| missense | 13 | 95 | 56 | 84 |
PlasmoDB Total SNPs: 75
Non-coding: 53 | Synonymous: 14 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 449 | Molecular Weight (kDa): 51.939
UniProt ID(s): C0H5A4
PDB ID(s): None
Isoelectric Point: 9.68
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 32629040 | The Small Nuclear Ribonucleoprotein Polypeptide A (SNRPA) binds to theG-quadruplex of the BAG-1 5'UTR | Bolduc F, Turcotte MA, Perreault JP | 10.1016/j.biochi.2020.06.013 |
| 35392763 | LINC01088 promotes the growth and invasion of glioma cells through regulating small nuclear ribonucleoprotein polypeptide A transcription | Peng T, Chen DL, Chen SL | 10.1080/21655979.2022.2051786 |