Product Description: exosome complex component RRP40, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0000177 | cytoplasmic exosome (RNase complex) |
Component | GO:0000178 | exosome (RNase complex) |
Component | GO:0000176 | nuclear exosome (RNase complex) |
Function | GO:0003723 | RNA binding |
Process | GO:0071034 | CUT catabolic process |
Process | GO:0034475 | U4 snRNA 3'-end processing |
Process | GO:0043928 | exonucleolytic catabolism of deadenylated mRNA |
Process | GO:0000467 | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Process | GO:0071035 | nuclear polyadenylation-dependent rRNA catabolic process |
Process | GO:0071038 | nuclear polyadenyl |
Process | GO:0071049 | |
Process | GO:0034427 | |
Process | GO:0071051 | |
Process | GO:0006364 |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | expressed | 0.28 | 0.86 |
Trophozoite | expressed | 0.42 | 0.75 |
Schizont | expressed | 0.12 | 0.93 |
Gametocyte | expressed | 0.34 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1307000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.957 | MFS: -2.896 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1405500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEP5
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=1.08) with 1KQM (Global RMSD=11.77)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102463
Most Similar Human Ortholog: Q9NQT5
TM-align score: 0.81 | RMSD: 2.59
Seq Identity: 0.24 | Length: 222 / 245
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000107371 | exosome component 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 2 | 9 | 8 | 22 |
disruptive | 1 | 18 | 20 | 38 |
missense | 1 | 18 | 20 | 37 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 4 | 22 | 18 | 14 |
disruptive | 4 | 46 | 42 | 58 |
missense | 4 | 40 | 36 | 50 |
PlasmoDB Total SNPs: 63
Non-coding: 48 | Synonymous: 12 | Nonsynonymous: 2 | Stop Codon: 1
Protein Length: 245 | Molecular Weight (kDa): 28.292
UniProt ID(s): Q8IEP5
PDB ID(s): None
Isoelectric Point: 6.93
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR004088 | K Homology domain, type 1 |
InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
InterPro | IPR026699 | Exosome complex RNA-binding protein 1/RRP40/RRP4 |
InterPro | IPR036612 | K Homology domain, type 1 superfamily |
PFam | PF15985 | K Homology domain, type 1 |
Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
Superfamily | SSF54791 | K Homology domain, type 1 superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
30235972 | Disruption of the RNA exosome reveals the hidden face of the malaria parasitetranscriptome. | Droll D, Wei G, ..., Zhang Q | 10.1080/15476286.2018.1517014 |
37904946 | Comparative analyses of disease-linked missense mutations in the RNA exosomemodeled in budding yeast reveal distinct functional consequences in translation | Sterrett MC, Cureton LA, ..., Ghalei H | 10.18.562946 |
17159918 | Structural and biochemical characterization of the yeast exosome component Rrp40 | Oddone A, Lorentzen E, ..., Sattler M | 10.1038/sj.embor.7400856 |
15116429 | Screening for novel essential genes of Saccharomyces cerevisiae involved inprotein secretion | Davydenko SG, Juselius JK, ..., Keranen S | 10.1002/yea.1063 |
17391830 | Analysis of the Saccharomyces cerevisiae exosome architecture and of the RNAbinding activity of Rrp40p | Luz JS, Tavares JR, ..., Oliveira CC | 10.1016/j.biochi.2007.01.011 |
27777260 | Insight into the RNA Exosome Complex Through Modeling Pontocerebellar HypoplasiaType 1b Disease Mutations in Yeast | Fasken MB, Losh JS, ..., van Hoof A | 10.1534/genetics.116.195917 |