About Gene List

PF3D7_1307100 (UTP6)

Genome location: Pf3D7_13_v3:327,138..331,324(+)

Genome classification: Core

Function and Localization

Product Description: U3 small nucleolar RNA-associated protein 6, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0034388 Pwp2p-containing subcomplex of 90S preribosome
Component GO:0032040 small-subunit processome
Function GO:0030515 snoRNA binding
Process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.76 0.65
Trophozoite expressed 0.70 0.62
Schizont possibly expressed 0.50 0.73
Gametocyte not expressed 0.38 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1307100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -2.886 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1405600)

  • Relative Growth Rate: 0.12 ± 0.08
  • Confidence: 6.40

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEP4

"Best" AlphaFill ligand hit: NOJ (moranoline, Local RMSD=0.42) with 2YA2 (Global RMSD=22.87)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102475

Most Similar Human Ortholog: Q9NYH9

TM-align score: 0.55 | RMSD: 4.93

Seq Identity: 0.17 | Length: 404 / 1011

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000108651 UTP6 small subunit processome component

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 45 30 73
disruptive 36 121 65 153
missense 25 103 58 135

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 100 38 81
disruptive 59 265 121 254
missense 40 213 94 187

PlasmoDB Total SNPs: 174

Non-coding: 65 | Synonymous: 56 | Nonsynonymous: 53 | Stop Codon: 0

Protein Information

Protein Length: 1011 | Molecular Weight (kDa): 120.725

UniProt ID(s): Q8IEP4

PDB ID(s): None

Isoelectric Point: 5.46

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013949 U3 small nucleolar RNA-associated protein 6
PFam PF08640 U3 small nucleolar RNA-associated protein 6
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
32524281 Anti-infective nitazoxanide disrupts transcription of ribosome biogenesis-relatedgenes in yeast Xu S, Yamamoto N 10.1007/s13258-020-00958-0