Product Description: U3 small nucleolar RNA-associated protein 6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome |
Component | GO:0032040 | small-subunit processome |
Function | GO:0030515 | snoRNA binding |
Process | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | expressed | 0.76 | 0.65 |
Trophozoite | expressed | 0.70 | 0.62 |
Schizont | possibly expressed | 0.50 | 0.73 |
Gametocyte | not expressed | 0.38 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1307100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -2.886 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1405600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IEP4
"Best" AlphaFill ligand hit: NOJ (moranoline, Local RMSD=0.42) with 2YA2 (Global RMSD=22.87)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102475
Most Similar Human Ortholog: Q9NYH9
TM-align score: 0.55 | RMSD: 4.93
Seq Identity: 0.17 | Length: 404 / 1011
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000108651 | UTP6 small subunit processome component |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 10 | 45 | 30 | 73 |
disruptive | 36 | 121 | 65 | 153 |
missense | 25 | 103 | 58 | 135 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 15 | 100 | 38 | 81 |
disruptive | 59 | 265 | 121 | 254 |
missense | 40 | 213 | 94 | 187 |
PlasmoDB Total SNPs: 174
Non-coding: 65 | Synonymous: 56 | Nonsynonymous: 53 | Stop Codon: 0
Protein Length: 1011 | Molecular Weight (kDa): 120.725
UniProt ID(s): Q8IEP4
PDB ID(s): None
Isoelectric Point: 5.46
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR013949 | U3 small nucleolar RNA-associated protein 6 |
PFam | PF08640 | U3 small nucleolar RNA-associated protein 6 |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
32524281 | Anti-infective nitazoxanide disrupts transcription of ribosome biogenesis-relatedgenes in yeast | Xu S, Yamamoto N | 10.1007/s13258-020-00958-0 |