About Gene List

PF3D7_1307200

Genome location: Pf3D7_13_v3:331,110..333,003(-)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.28 0.87
Trophozoite expressed 0.64 0.65
Schizont expressed 0.22 0.87
Gametocyte expressed 0.71 0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1307200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.091 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1405700)

  • Relative Growth Rate: 0.06 ± 0.08
  • Confidence: 6.53

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEP3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103567

Most Similar Human Ortholog: O75937

TM-align score: 0.58 | RMSD: 3.74

Seq Identity: 0.25 | Length: 187 / 322

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000126698 DnaJ heat shock protein family (Hsp40) member C8
ENSG00000285317 DnaJ heat shock protein family (Hsp40) member C8

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 17 11 23
disruptive 10 43 27 70
missense 8 39 27 63

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 37 12 27
disruptive 15 91 52 104
missense 9 82 48 80

PlasmoDB Total SNPs: 126

Non-coding: 110 | Synonymous: 7 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 322 | Molecular Weight (kDa): 38.913

UniProt ID(s): Q8IEP3

PDB ID(s): None

Isoelectric Point: 5.79

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001623 DnaJ domain
InterPro IPR036869 Chaperone J-domain superfamily
PFam PF00226 DnaJ domain
Superfamily SSF46565 Chaperone J-domain superfamily

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108