PF3D7_1307400

Genome location: Pf3D7_13_v3:335,852..337,263(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.06	0.96
Gametocyte	not expressed	0.49	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1307400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.835 | MFS: -2.19 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEP1

"Best" AlphaFill ligand hit: PT1 (pteroic acid, Local RMSD=4.11) with 6JWS (Global RMSD=14.99)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_116784

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	34	19	26
disruptive	12	55	33	73
missense	9	47	30	65

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	60	17	38
disruptive	29	127	60	109
missense	16	102	45	77

PlasmoDB Total SNPs: 67

Non-coding: 23 | Synonymous: 34 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 387 | Molecular Weight (kDa): 45.203

UniProt ID(s): Q8IEP1

PDB ID(s): None

Isoelectric Point: 5.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF63829	N/A