PF3D7_1307700

Genome location: Pf3D7_13_v3:343,464..348,264(+)

Genome classification: Core

Function and Localization

Product Description: TOM1-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.43	0.81
Trophozoite	possibly expressed	0.39	0.77
Schizont	expressed	0.63	0.64
Gametocyte	not expressed	0.47	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1307700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.044 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEN8

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=2.12) with 2QGA (Global RMSD=23.01)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532531

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	86	42	73
disruptive	55	232	126	305
missense	37	211	118	266

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	157	62	87
disruptive	93	535	225	492
missense	62	462	180	308

PlasmoDB Total SNPs: 193

Non-coding: 90 | Synonymous: 56 | Nonsynonymous: 46 | Stop Codon: 1

Protein Information

Protein Length: 1235 | Molecular Weight (kDa): 144.245

UniProt ID(s): Q8IEN8

PDB ID(s): None

Isoelectric Point: 5.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008942	ENTH/VHS
PFam	N/A	N/A
Superfamily	SSF48464	ENTH/VHS