PF3D7_1307800 (CEP170)

Genome location: Pf3D7_13_v3:348,316..351,043(-)

Genome classification: Core

Function and Localization

Product Description: centrosomal protein CEP170, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0003729	mRNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.22	0.89
Trophozoite	expressed	0.46	0.73
Schizont	expressed	0.05	0.96
Gametocyte	expressed	0.33	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1307800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.839 | MFS: -2.317 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEN7

"Best" AlphaFill ligand hit: NAI (nadh, Local RMSD=7.20) with 5H04 (Global RMSD=23.23)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102703

Most Similar Human Ortholog: Q8TAD8

TM-align score: 0.41 | RMSD: 4.77

Seq Identity: 0.35 | Length: 202 / 561

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000163877	Smad nuclear interacting protein 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	27	23	31
disruptive	20	90	48	105
missense	14	86	43	91

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	59	23	33
disruptive	35	206	85	145
missense	24	171	74	100

PlasmoDB Total SNPs: 225

Non-coding: 112 | Synonymous: 59 | Nonsynonymous: 54 | Stop Codon: 0

Protein Information

Protein Length: 561 | Molecular Weight (kDa): 68.284

UniProt ID(s): Q8IEN7

PDB ID(s): None

Isoelectric Point: 9.49

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000253	Forkhead-associated (FHA) domain
InterPro	IPR008984	SMAD/FHA domain superfamily
PFam	PF00498	Forkhead-associated (FHA) domain
Superfamily	SSF49879	SMAD/FHA domain superfamily

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108