PF3D7_1307900

Genome location: Pf3D7_13_v3:351,108..355,213(-)

Genome classification: Core

Function and Localization

Product Description: tripartite motif protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.03	0.99
Trophozoite	no data	0.13	0.92
Schizont	no data	1.03	0.50
Gametocyte	no data	0.28	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1307900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.039 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEN6

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=2.96) with 6JWQ (Global RMSD=45.79)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_153405

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	30	34	57
disruptive	25	79	68	176
missense	15	65	55	143

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	78	38	67
disruptive	39	232	114	261
missense	18	179	100	173

PlasmoDB Total SNPs: 204

Non-coding: 135 | Synonymous: 34 | Nonsynonymous: 34 | Stop Codon: 1

Protein Information

Protein Length: 886 | Molecular Weight (kDa): 105.384

UniProt ID(s): Q8IEN6

PDB ID(s): None

Isoelectric Point: 6.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000315	B-box-type zinc finger
PFam	N/A	N/A
Superfamily	SSF57845	N/A