PF3D7_1308000

Genome location: Pf3D7_13_v3:355,912..359,788(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.28	0.84
Schizont	expressed	1.93	0.25
Gametocyte	not expressed	0.51	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1308000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 4 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.166 | MFS: -2.924 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5A5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533548

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	40	27	48
disruptive	24	98	57	137
missense	17	76	51	113

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	70	33	65
disruptive	57	225	104	251
missense	31	171	88	164

PlasmoDB Total SNPs: 152

Non-coding: 83 | Synonymous: 44 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 830 | Molecular Weight (kDa): 100.013

UniProt ID(s): C0H5A5

PDB ID(s): None

Isoelectric Point: 5.64

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A