PF3D7_1308100

Genome location: Pf3D7_13_v3:359,803..360,998(+)

Genome classification: Core

Function and Localization

Product Description: CCAAT-binding transcription factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0008623	CHRAC
Component	GO:0008622	epsilon DNA polymerase complex
Function	GO:0003677	DNA binding
Function	GO:0003700	DNA-binding transcription factor activity
Function	GO:0031490	chromatin DNA binding
Process	GO:0006974	cellular response to DNA damage stimulus
Process	GO:0031507	heterochromatin assembly
Process	GO:0006272	leading strand elongation
Process	GO:0042766	nucleosome mobilization
Process	GO:0006355	regulation of transcription, DNA-templated

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	expressed	0.20	0.86
Schizont	expressed	0.04	0.97
Gametocyte	expressed	0.19	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1308100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.622 | MFS: -2.452 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1406600)

Relative Growth Rate: 0.98 ± 0.09
Confidence: 6.12

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1406600)

Modification: Disrupted | RMgm-3762

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEN4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171482

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	12	5	12
disruptive	1	14	7	27
missense	1	14	7	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	28	3	11
disruptive	1	37	14	34
missense	1	34	13	21

PlasmoDB Total SNPs: 55

Non-coding: 45 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 2

Protein Information

Protein Length: 152 | Molecular Weight (kDa): 17.619

UniProt ID(s): Q8IEN4

PDB ID(s): None

Isoelectric Point: 4.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003958	Transcription factor CBF/NF-Y/archaeal histone domain
InterPro	IPR009072	Histone-fold
PFam	PF00808	Transcription factor CBF/NF-Y/archaeal histone domain
Superfamily	SSF47113	Histone-fold