About Gene List

PF3D7_1308300 (RPS27)

Genome location: Pf3D7_13_v3:370,778..373,004(+)

Genome classification: Core

Function and Localization

Product Description: 40S ribosomal protein S27

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022627 cytosolic small ribosomal subunit
Component GO:0005634 nucleus
Function GO:0003723 RNA binding
Function GO:0003735 structural constituent of ribosome
Process GO:0000028 ribosomal small subunit assembly
Process GO:0006412 translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.59 0.72
Trophozoite expressed 0.87 0.54
Schizont expressed 0.15 0.90
Gametocyte not expressed 0.82 0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1308300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.12 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1406800)

  • Relative Growth Rate: 0.03 ± 0.06
  • Confidence: 7.04

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEN2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt Protein Name Species Homology Source BindingDB Ligands
P42677 40S ribosomal protein S27 Homo sapiens HOGENOM, OMA, OrthoDB CHEMBL4248722-pyridinecarboxamide deriv. 8bAminopyridine-Based Inhibitor 6eCHEMBL2089252...

Orthology Information

Ortholog Group (OrthoMCL): OG6_100584

Most Similar Human Ortholog: Q71UM5

TM-align score: 0.99 | RMSD: 0.37

Seq Identity: 0.68 | Length: 82 / 82

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000177954 ribosomal protein S27
ENSG00000185088 ribosomal protein S27 like

Protein Information

Protein Length: 82 | Molecular Weight (kDa): 9.142

UniProt ID(s): Q8IEN2

PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP

Isoelectric Point: 8.4

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000592 Ribosomal protein S27e
InterPro IPR011332 Zinc-binding ribosomal protein
PFam PF01667 Ribosomal protein S27e
Superfamily SSF57829 Zinc-binding ribosomal protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 97

Non-coding: 93 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
24913268 Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine Wong W, Bai XC, ..., Scheres SH 10.7554/eLife.03080
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596