PF3D7_1308400

Genome location: Pf3D7_13_v3:373,028..393,614(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.79	0.66
Trophozoite	expressed	2.23	0.18
Schizont	expressed	1.85	0.34
Gametocyte	possibly expressed	1.38	0.38

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1308400

Resistome Missense Mutations: Q276K, K4195R

Resistome Compounds with Missense Mutations: GNF-Pf-3600, MMV009108

Resistome # Samples with Disruptive Mutations: 6 (6 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.011 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_211632

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	63	397	222	448
disruptive	361	1307	657	1383
missense	243	1103	569	1171

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	126	766	319	498
disruptive	656	2474	940	1748
missense	429	2030	781	1246

PlasmoDB Total SNPs: 1072

Non-coding: 168 | Synonymous: 480 | Nonsynonymous: 414 | Stop Codon: 10

Protein Information

Protein Length: 6147 | Molecular Weight (kDa): 737.703

UniProt ID(s): C0H5A6

PDB ID(s): None

Isoelectric Point: 9.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A