PF3D7_1308500

Genome location: Pf3D7_13_v3:393,715..395,881(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.6.1.15 (Nucleoside-triphosphate phosphatase)

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.12	0.94
Trophozoite	no data	0.47	0.72
Schizont	no data	0.13	0.92
Gametocyte	no data	0.48	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1308500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.931 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1407000)

Relative Growth Rate: 0.68 ± 0.35
Confidence: 3.47

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1407000)

Modification: Disrupted | RMgm-3766

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEN0

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.60) with 6JWR (Global RMSD=21.42)

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.6.1.15	nucleoside-triphosphate phosphatase	ATPADPNaFRNAEDTAdATPdTTPdCTPdGTPHOClrNTPMgCl2...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107127

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	24	11	25
disruptive	6	38	31	74
missense	6	37	31	62

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	36	13	34
disruptive	10	100	62	129
missense	10	87	59	84

PlasmoDB Total SNPs: 113

Non-coding: 89 | Synonymous: 18 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 359 | Molecular Weight (kDa): 42.985

UniProt ID(s): Q8IEN0

PDB ID(s): None

Isoelectric Point: 7.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	N/A	N/A
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase