PF3D7_1308600

Genome location: Pf3D7_13_v3:396,734..401,269(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.04	0.98
Trophozoite	no data	0.30	0.82
Schizont	no data	0.04	0.97
Gametocyte	no data	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1308600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.238 | MFS: -2.756 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5A7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533414

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	76	41	110
disruptive	70	266	136	274
missense	53	239	125	234

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	177	74	127
disruptive	129	548	233	524
missense	93	450	193	318

PlasmoDB Total SNPs: 208

Non-coding: 49 | Synonymous: 75 | Nonsynonymous: 84 | Stop Codon: 0

Protein Information

Protein Length: 1405 | Molecular Weight (kDa): 171.567

UniProt ID(s): C0H5A7

PDB ID(s): None

Isoelectric Point: 9.28

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A